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Avastus Preclinical Services specializes in the use of many in vivo infectious disease models. We have established a wide array of animal infection models for the use in preclinical efficacy evaluation of anti-infective agents. Our infectious disease models use a wide range of pathogens and can be tailored to any study design scheme. Some of the models include

Avastus Rat & Mouse Infection/Antimicrobial Models

  • Thigh Infection Models
  • Lung Infection Models
  • Systemic Infection Models
  • Kidney Infections
  • UTI Infections
  • Intra-abdominal Abscess Model
  • PK/PD
  • Virulence
  • Bacterial as well as yeast & other fungi models
  • Abscess Model
  • BAL/ELF (rats)

In Vitro Models

  • MIC/MBC testing
  • Viability testing

Our models utilize a broad range of pathogens which include Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, Enterococcus faecalis, Staphylococcus aureus, Listeria monocytogenes, Streptococcus pneumoniae, Haemophilus influenzae, Streptococcus pyogenes, Pseudomonas aeruginosa and Clostridium difficile.

Disease models can be altered to fit client study needs, we also offer consulting services and can help in the development of new models based on client study needs.

  • Mouse lung disease model efficacy chart
  • Mouse thigh infection antibiotic efficacy chart